Chronic Pain, Neuroinflammation, and Central Sensitization in Migraine and Fibromyalgia

Alex Vasquez, DC, ND, DO, FACN

Presentation Overview:

This presentation will provide an overview of the most important concepts in chronic pain and central sensitization and will focus on migraine and fibromyalgia as variations on these themes. Dr. Vasquez will update and extend the models that he initially presented for peer-reviewed publication in 2008 and will discuss some of the newer details, such as for small fiber neuropathy in fibromyalgia and CGRP release in migraine. Are these patients better treated with drugs, or with nutrients, or a combination? Are the new drugs for these conditions to be considered legitimate “breakthroughs” or simply more pharmaceutical marketing hype? What are some estimates of the effectiveness, cost-effectiveness, and ethical distribution of resources with regard to treating the millions of people with these conditions? All of these questions and more will be reviewed and answered during this two-hour presentation, with some time allotted for additional questions and answers toward the end.

Leaning Objectives:

  1. Demonstrate an understanding of central sensitization and be able to illustrate a complete biological model of the pathophysiology and biologically appropriate treatment
  2. Explain the pathophysiology of migraine and trigeminal nerve activation
  3. Explain the causes and consequences of mitochondrial dysfunction
  4. Outline a biologically appropriate plan for conditions of chronic pain and central sensitization, using migraine and fibromyalgia as examples